The Toska Lab’s research focus is centered on elucidating the role that transcriptional and epigenetic regulators play in normal and cancer development, and therapeutic response. We are passionate about asking clinically relevant questions and translating basic laboratory findings into therapeutic applications to benefit cancer patients while at the same time providing new insights into the fundamental mechanisms of how epigenetic regulators regulate transcription and dictate cell identity. To achieve these goals, the Toska Lab aims to undertake a multidisciplinary approach integrating biochemistry, cell signaling, genomics and epigenomics at bulk and single cell level, organoid technology, and mouse genetics to study the fundamental processes by which epigenetic regulators regulate transcription, cross-talk with signaling pathways, and have the ability to drive transformation and dictate therapeutic response in nuclear receptor-dependent cancers. Our laboratory will be comprised of scientists from different fields who are driven to study epigenetic regulation in normal and cancer development and to identify new therapeutic opportunities.

• Cancer Biology
• Cellular Stress and Cell Signaling
• Genetics, Genomics and Gene Regulation
• Translational Research
• Epigenetics
• Breast Cancer